欧盟食品安全局发布食品中赭曲霉毒素A的风险评估

　　食品伙伴网讯    2020年5月13日，欧盟食品安全局（EFSA）发布关于食品中赭曲霉毒素A（Ochratoxin A）的风险评估。

 

　　据了解，赭曲霉毒素A是由曲霉属和青霉属菌株产生的一种有毒真菌次级代谢产物，具有很强的肝脏毒性和肾脏毒性，并有致畸、致突变和致癌作用，是各种食物中的污染物。部分原文报道如下：

 

　　The European Commission asked EFSA to updat their 2006 opinion on ochratoxin A （OTA） in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and found as a contaminant in various foods. OTA causes kidney toxicity in different animal species and kidney tumours in rodents. OTA is genotoxic both in vitro and in vivo; however, the mechanisms of genotoxicity are unclear. Direct and indirect genotoxic and non‐genotoxic modes of action might each contribute to tumour formation. Since recent studies have raised uncertainty regarding the mode of action for kidney carcinogenicity, it is inappropriate to establish a health‐based guidance value （HBGV） and a margin of exposure （MOE） approach was applied. For the characterisation of non‐neoplastic effects, a BMDL10 of 4.73 μg/kg body weight （bw） per day was calculated from kidney lesions observed in pigs. For characterisation of neoplastic effects, a BMDL10 of 14.5 μg/kg bw per day was calculated from kidney tumours seen in rats. The estimation of chronic dietary exposure resulted in mean and 95th percentile levels ranging from 0.6 to 17.8 and from 2.4 to 51.7 ng/kg bw per day, respectively. Median OTA exposures in breastfed infants ranged from 1.7 to 2.6 ng/kg bw per day, 95th percentile exposures from 5.6 to 8.5 ng/kg bw per day in average/high breast milk consuming infants, respectively. Comparison of exposures with the BMDL10 based on the non‐neoplastic endpoint resulted in MOEs of more than 200 in most consumer groups, indicating a low health concern with the exception of MOEs for high consumers in the younger age groups, indicating a possible health concern.

 

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