欧盟评估一种内切-1,4-β-木聚糖酶作为所有禽类、仔猪和小型生长猪种饲料添加剂的安全性和有效性

 

　　据了解，该添加剂是由Komagataella phaffii CGMCC 7.371 生产的。经过评估，专家小组认为在建议的使用条件下该添加剂对目标物种、消费者和环境是安全的。该小组认为，在2000 U/kg全价饲料的剂量下，该添加剂对产蛋鸟类和仔猪（哺乳和断奶）是有效的，在1000 U/kg全价饲料的剂量下，对所有其他鸟类是有效的。部分原文报道如下：

 

　　Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of endo-β-1,4-xylanase (VTR-xylanase) as a zootechnical feed additive for all avian species, piglets (suckling and weaned) and minor growing porcine species. VTR-xylanase is available in a powder and a liquid form and is produced by a genetically modified strain of Komagataella phaffii (CGMCC 7.371). The genetic modification of the production strain does not give rise to safety concerns. Viable cells of the production strain and its DNA were not detected in the final products. The additive does not pose any safety concern regarding the production strain. VTR xylanase (powder/liquid) produced by Komagataella phaffii CGMCC 7.371 is safe for all avian species, piglets and minor growing porcine species at the proposed conditions of use. The use of both forms of the additive under assessment in animal nutrition under the proposed conditions of use raises no safety concerns for consumers or for the environment. The liquid and powder formulations of VTR-xylanase are non-irritant to eyes but should be considered skin sensitisers. No conclusions can be drawn on the potential of the final formulations of the additive to be irritant to skin. Due to the proteinaceous nature of the active substance, the additive is a respiratory sensitiser. The additive has the potential to be efficacious in all laying birds and piglets (suckling and weaned) from all Suidae at 2,000 U/kg and in all other avian species/categories at 1,000 U/kg feed.

 

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