欧盟评估一种内切-1,4-β-木聚糖酶的安全性

　　食品伙伴网讯  2020年6月3日，欧盟食品安全局（EFSA）发布一种内切-β-1,4木聚糖酶（endo‐1,4‐β‐xylanase）安全性的评估结果。

 

　　据了解，该食品酶是由AB Enzymes GmbH公司用转基因里氏木霉（Trichoderma reesei）菌株RF 5427生产的，旨在用于烘焙、酿造和谷物加工、蒸馏酒精生产以及用于生产淀粉和麸质的谷物处理中。经过评估，在预期使用条件下，这种食品酶不会引起安全问题。部分原文报道如下：

 

　　The food enzyme endo‐1,4‐β‐xylanase （4‐β‐D‐xylan xylanohydrolase; EC 3.2.1.8） is produced with the genetically modified Trichoderma reesei strain RF 5427 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA . It is intended to be used in baking, brewing and cereal‐based processes, distilled alcohol production and grain treatment for the production of starch and gluten fractions. Since residual amounts of the food enzyme are removed by distillation and during grain treatment, dietary exposure was only calculated for baking, brewing and cereal‐based processes. based on the proposed maximum use levels, dietary exposure to the food enzyme–Total Organic Solids （TOS ） was estimated to be up to 0.119 mg TOS /kg body weight （bw） per day. Genotoxicity tests did not raise a safety concern. The Panel identified a no observed adverse effect level at the highest dose tested of 939 mg TOS /kg bw per day in a repeated dose 90‐day oral toxicity study in rats, resulting in a margin of exposure of at least 7,890. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched and no matches were found. The Panel considered that allergenicity can be excluded for distilled alcohol production.

 

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