欧盟评估来自一种转基因里氏木霉菌株的溶血磷脂酶的安全性

　　食品伙伴网讯  2019年1月22日，欧盟食品安全局发布关于来自转基因里氏木霉RF7206菌株的食品酶溶血磷脂酶（lysophospholipase）安全性的评估结果。

 

　　据了解，这种酶旨在用于生产葡萄糖糖浆的淀粉加工中。经过评估，专家小组得出结论，这种食品酶在预期使用条件下不会引起安全问题。

 

　　部分原文报道如下：

 

　　The food enzyme lysophospholipase （EC 3.1.1.5） is produced with the genetically modified Trichoderma reesei strain RF7206 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The lysophospholipase food enzyme is intended to be used in starch processing for the production of glucose syrups. Residual amounts of total organic solids （TOS） are removed by the purification steps applied during the production of glucose syrups, consequently, dietary exposure was not calculated. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level at the highest dose tested of 927 mg TOS/kg body weight （bw） per day. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended condition of use, the risk of allergic sensitisation and elicitation reactions upon dietary exposure to this food enzyme cannot be excluded, but the likelihood of such reactions to occur is considered to be low. based on the data provided and the removal of TOS during the intended food production process, the Panel concluded that this food enzyme does not raise safety concerns under the intended conditions of use.

 

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