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欧盟评估一种葡萄糖氧化酶的安全性

放大字体  缩小字体 时间:2018-07-11 15:00 来源:食品伙伴网 作者:  浏览:31  原文:
核心提示:据欧盟食品安全局(EFSA)消息,近日,欧盟食品安全局就一种葡萄糖氧化酶(glucose oxidase)用于烘焙过程的安全性发布意见。
     食品伙伴网讯  据欧盟食品安全局(EFSA)消息,近日,欧盟食品安全局就一种葡萄糖氧化酶(glucose oxidase)用于烘焙过程的安全性发布意见。
 
    这种葡萄糖氧化酶是利用转基因米曲霉产生的食品酶。欧盟食品安全局专家组对这种葡萄糖氧化酶的安全性进行了评估。专家组经过评估认为,这种葡萄糖氧化酶在预期最大使用量范围内不存在安全问题,预期最大使用量为每天341mg TOS/kg 体重。
 
    部分原文如下:
 
    The food enzyme is a glucose oxidase (beta‐D‐glucose:oxygen 1‐oxidoreductase; EC 1.1.3.4) produced with a genetically modified strain of Aspergillus oryzae strain NZYM‐KP by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme does not contain the production organism or DNA; therefore, there is no safety concern for the environment. The glucose oxidase is intended to be used in baking processes. based on the maximum use levels recommended and individual consumption data from the EFSA Comprehensive European Food Consumption Database, dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 0.156 mg TOS/kg body weight (bw) per day in European populations. The food enzyme did not induce gene mutations in bacteria or chromosome aberrations in human lymphocytes. The subchronic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rodents. A no‐observed‐adverse‐effect level was derived (341 mg TOS/kg bw per day), which compared with the estimated dietary exposure results in a sufficiently high margin of exposure. The allergenicity was evaluated by comparing the amino acid sequence to those of known allergens and one match with a fungal contact allergen was found. The Panel considered that, under the intended condition of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered low. based on the microbial source, the genetic modifications, the manufacturing process, the compositional and biochemical data, the estimated dietary exposure and the findings in the toxicological studies, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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日期:2018-07-11
 
 地区: 国外 欧盟
 行业: 糖业 进出口
 标签: EFSA 欧盟食品安全局 葡萄糖

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