欧盟评估一种蛋氨酸铬螯合物作为饲料添加剂的安全性和有效性　

　　食品伙伴网讯  2020年2月26日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组就Availa®Cr（DL‐蛋氨酸铬螯合物（chromium chelate of DL‐methionine））作为奶牛饲料添加剂的安全性和有效性发表科学意见。

 

　　经过评估，专家小组认为在建议使用水平（奶牛每天8mg铬来自Availa®Cr；大约0.4mg铬/kg全价饲料）是安全的，但无法确定其有效性。部分原文报道如下：

 

　　Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Availa®Cr （active compound: chromium chelate of DL‐methionine） as a feed additive for dairy cows. The EFSA Panel on Additives and Products or Substances used in Animal Feed （FEEDAP） Panel was assigned to this mandate. The tolerance study did not show adverse effects with respect to body weight, milk yield, haematology and blood biochemistry up to the 10‐fold overdose of chromium from Availa®Cr; however, owing to deficiencies in design and reporting of the study, it provided only supportive evidence on the safety of the additive. A safe level for dairy cows could be derived from a toxicological study with laboratory rodents. Taking all together, the FEEDAP Panel considers the maximum recommended use level （8 mg Cr from Availa®Cr/cow per day; about 0.4 mg Cr/kg complete feed） as safe. Chromium DL‐Met shows a genotoxic activity in vitro that is not expressed in vivo after systemic exposure; although no data on genotoxicity at the site of contact are available, the Panel notes that chromium（III） is not carcinogenic and concludes that chromium DL‐Met is unlikely to pose a carcinogenic risk at levels occurring in the diet.

 

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