欧盟食品安全局就内分泌干扰物质的危害评估发布意见

    食品伙伴网讯   据欧盟食品安全局（EFSA）消息，3月20日欧盟食品安全局专家组就内分泌干扰物质的危害评估发布了意见。

    欧盟食品安全局专家组阐述了内分泌干扰物质的鉴定标准，内分析干扰物质对人体健康以及环境影响的现行测定方法。

    专家组认为，内分泌干扰物质可以按照以下3种方法鉴定：内分泌活性、不良效应、内分泌活性与不良效应之间可能的联系。

    部分原文报道如下：

    Upon request of the European Commission, the Scientific Committee （SC） of the European Food Safety Authority reviewed existing information related to the testing and assessment of endocrine active substances （EASs） and endocrine disruptors （EDs）。 This work was conducted by a working group of experts in endocrinology, risk assessment and toxicology, together with observers from other EU agencies, namely EMA, ECHA and EEA. To distinguish between EDs and other groups of substances with different modes of action, it was concluded that an ED is defined by three criteria: the presence of i） an adverse effect in an intact organism or a （sub）population; ii） an endocrine activity; and iii） a plausible causal relationship between the two. As scientific criteria for adversity have not been generally defined, specific criteria for endocrine disrupting effects could not be identified.

    Hence, expert judgement is required to assess on a case-by-case basis the （eco）toxicological relevance of changes at the molecular to individual and/or （sub）population level following exposure to an EAS. The SC concluded that a reasonably complete suite of standardised assays for testing the effects of EASs is （or will soon be） available for the oestrogenic, androgenic, thyroid and steroidogenic modalities in mammals and fish, with fewer tests for birds and amphibians.

    原文链接：<http://www.efsa.europa.eu/en/efsajournal/pub/3132.htm>

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